Although the discussion about the asymmetry of representation and of communication have become a common place, I have observed that the symmetrical representation of the sign remains constant.The model I propose starts from the triadic analysis of the sign made by C. S. Peirce, completed with discussion on the representamen as ground, as well as on the immediate object and the dynamic object, respectively the immediate, dynamic, and final interpretant. Then I add references to the peircean continuum where three global properties are entangled - genericity, reflexivity, and modality - and I refer to the asymmetry found after discovering discontinuity at the representamen level (firstness), limited or finite continuity at the object level (secondness) and unlimited continuity at the interpretant level (thirdness).In the second part of the paper, I take a look on the asymmetry of the semiosis, which comprises three aspects, depending on its focus on one of the three components of the sign: the semiosis of the discovery of identity, focused on the representamen, the semiosis of the otherness (Levinas), focused on the object, and the semiosis of the conflict of interpretations (Ricoeur), focused on the interpretant. The latter is determinant, in my opinion, of what we call unlimited semiosis, which enables the ontological opening that confirms the implication of the asymmetry by the temporal becoming (Husserl).Finnaly, I will try to give an answer from a semiotic point of view to the question: can be knowledge without asymmetry?