Music-making is a behavior observed in all human cultures, suggesting that musicality is a part of human nature. Thus, although music is filled with conventional signs musical communication must also be subject to species-specific rules that limit the scope and content of musical meaning. In order to understand the entire range of meanings expressed through music, it is therefore necessary to take into account the biological constraints that impact communication. The presentation aims to show how knowledge about the evolution of animal communication can expand our understanding of musical meaning. For example, pitch can serve as a cue of size or just the presence of an animal. Apart from that, due to the ancient evolutionary transformation of pitch cues into signals, pitch in human vocalization has become a vehicle for many conservative meanings such as dominance, politeness, and mitigation. All these conservative meanings can be still present in music and impact the process of their conceptualization. Probably because of that the experience of pitch in music is usually described in terms of metaphors, the character of which manifests certain similarities. It will be proposed to include these and other meanings deeply rooted in our biology into the theory of musical signification as important elements to be taken into account in music analysis methods.