Juri Lotman’s concept of semiosphere describes culture as a spatial phenomenon. I approach it as a semiotic framework of analysis and discuss its relation to spatial computational methods which are rarely combined with each other. I compare computational approaches pertaining multidimensional vector spaces with Lotman’s framework of semiosphere to demonstrate how these approaches may transform the understanding of phenomena under study and what is to gain by this comparison. On the one hand, such multidimensional vector spaces go beyond two- and three-dimensions although they are often transformed to it for visualization purposes. There are well-known problems of understanding the relations within such multidimensional space and with their visual depictions. Analysis of cultural phenomena as a semiosphere may encounter similar difficulties. For example, there may be different centers and peripheries depending on different features; what seems distant from one perspective may not be so from another. On the other hand, these methods are used to analyse dynamic cultural processes which gain their meaning only through interpretation. Semiotics is well aware of it and brings into focus e.g. the role of interpreter in transforming clusters, collections of seemingly related elements. Finally, these comparisons provide an example of interdisciplinary approach that seek to overcome simple qualitative-quantitative division.