Avatar Therapy (AT) is a clinical protocol for the treatment of auditory hallucinations in schizophrenia. It consists of the patient’s exposure, via Virtual Reality, to an avatar - co-designed by the therapist and the individual under care - that embody the facial features that the patient assigns to the voice he/she hears in the head. This therapy has for several years now shown promising results in reducing the onset and persistence of hallucinations. However, it deserves to be discussed not only in terms of its clinical efficacy but also for its philosophical and semiotic implications. The effectiveness of the treatment, in fact, correlates with processes of great interest to those involved in facial semiotics and embodied cognition: participatory sense-making, multimodality, forms of techno-disembodiment and re-embodiment. I will outline how these processes unfold during the AT sessions, and focus on the role that the digital face plays in mediating the relationship between the therapist and the patient, as well as that between the patient and reality itself. Particular emphasis will be put on the avatars themselves, which will be analyzed and framed as tools useful for assessing how the psychopathological experience can be given new meanings (re-signification) and sensorially restructured (re-sensualization).