Drawing upon Donald Brown's framework of Human Universals, this study seeks to point out the existence of universal and supra-cultural human aspects that need to be carefully evaluated and known to be applied in advertising and marketing activities through the lens of communication and semiotics.These universals are considered fundamental to human societies and offer a basis for understanding cultural similarities and differences. However, it's important to note that while these universals are prevalent across cultures, the specific manifestations and interpretations of these traits may vary widely by region, social background, beliefs, age, ethnic group, etc.Contemporary society and the advertising world have embraced diversity as a communication tool, recognizing the richness and complexity of human experiences and identities. In an increasingly interconnected world, advertisers have shifted towards acknowledging and celebrating diversity, engaging with specific subcultures and marginalized communities in meaningful ways.In doing so, advertisers use images, signs, or language, for example, that may have clear meaning for a certain subculture but not penetrate others. This becomes a major challenge for brands and their impact on consumption, revenues, and symbolic connection.Ultimately, this study contributes to the field of communication and semiotics by offering new insights into the universal appeal of advertising and its impact on human behavior and society. It highlights the importance of considering Human Universals in advertising research and practice to create messages that resonate with audiences locally, regionally, or globally.