The Cofán people are located in the Colombian-Ecuadorian Amazon. In recent history this town has faced many problems that put it at risk of extinction. The process of destruction of the Cofán people is constituted as a semi-ocide to the extent that it annihilates the forms of expression, their own language, their own practices (songs, ceremonies) and the specific systems of meaning of this human group. In the reservation of Santa Rosa del Guamuez-Putumayo-Colombia, the Cofán people have been developing an artistic revitalization project that is supported by their spiritual practices. U'fa Henfa (sounds of Yagé) is a group made up of teachers and students who sing in their own language, paint murals and make videos that express the mystical experiences they have in the Yagé ceremonies. U'fa Henfa is configured as the most important artistic and organizational experience implemented today in the Reservation. This paper aims to understand the way in which the message of Yagé is expressed in some members of U'fa Henfa. It is based on the strong idea that in the Yagé rituals a communication is established with the plant and with the non-human. In the ceremony, the members of U'fa Henfa access messages that are later materialized in musical, visual and audiovisual media. Through the semiotic analysis of some works of the group, we will reflect on the appropriate meaning systems for the expression of the Yagé message.