As part of cartographic, semiotic, and history research on the cultural landscape transformations of the mining city of Zacatecas in Mexico, this text shows the different kinds of descriptions of Latin American cities since the colonial age to nowadays, to contrast the discursive strategies and modes of representation, and show how it affects the definition of identity. Studying contemporary and polymorphic cities is a challenge because the frontiers are erased in the context of globalization, irregular growth, and rhizome structures. It is communicated, therefore, that cities are transformed through identities and how links are built with their ancestral roots, and their ways of breaking away from coloniality. In this sense, it is interesting to address the decolonial meaning in Latin American urban life. Postmodern cities are conceived as hyper-semiotic places: they can be open or closed systems that embrace or reject foreignness. This text identifies the methodological perspectives of analysis of the city as a territory and symbolic space to build an interdisciplinary model and discusses the concept of the city itself as home, work, individuality, social interaction, surveillance, and knowledge. Topography, geography, arts, semiotics, and technology converge to try to encompass the unfathomable city with our eyes.