Exploring the convergence between advertising and design reveals the profound influence that colors exert in creating environments that evoke perceptual reactions. However, the scenario of approximately 350 million people worldwide dealing with some degree of color vision deficiency instigates an opportunity to explore how reality is perceived and interpreted within a system of signs, especially among individuals with such deficiencies. To unravel these dynamics, this study adopted a comprehensive methodology. (1), artificial intelligence was used to generate and analyze information about symbolic processes, encompassing textual, visual, and chromatic elements. (2), detailed interviews were conducted to gain insights directly from participants. (3), a comparative analysis, based on C. S. Peirce's semiotic framework, was elaborated. This methodological triad facilitated a nuanced understanding of how individuals perceive advertising content. By identifying points of convergence and divergence in their perceptions, the study contributes to a richer understanding of diverse perspectives. From this perspective, it becomes evident that considerations of color vision deficiencies are imperative in designing effective advertising campaigns. Finally, this research highlights the importance of inclusivity in advertising design, advocating for strategies that accommodate varying perceptual capacities. Such insights not only enrich our understanding of advertising dynamics but also advocate for a more equitable and effective communication landscape.