This article examines the concept of reality by analyzing both its tradition in philosophy and its relation to the semiotic theories of Ernst Cassirer, Charles S. Peirce, and Ferdinand de Saussure. We focus on myth, questioning its role in the apprehension, creation, and management of reality within the semiosphere and in relation to science, art, and religion. Ernst Cassirer suggests that reality is complex and can only be apprehended through "symbolic forms," which he defines as "organs" for "apprehending the reality of the mind." Among these symbolic forms are verbal language, myth, science, or art. Each, in its own way, allows for the apprehension of a part of a complex reality (Guillén, 2022b). Cassirer's work can be related to that of Peirce on several points, not only through the comparison between Peirce's phaneroscopy and the categories of divine gods (Guillén, 2022a, 2022b) but also to better understand the phenomena of interpreting one or multiple complex realities. Peirce, like Cassirer later, problematizes reality not as such but as it is apprehended (mediated) by thought.(1931, 7, 5, §4) ) Regarding the role that myth, art and fiction play with reality, Blumenberg indicates that this relationship is complex (1963, 1971, 1979) and lists a series of conceptions of reality that we analyze through the theoretical frameworks of Cassirer and Peirce. How, through the study of Peirce's and Cassirer work on reality, can we better understand the cultural role of myth, in relation to science, art, and religion as a means to grasp reality?