In the proposed paper the nature-culture entanglement is considered in the lens of semiotics. The main research questions posed in the talk are the usage of specific metaphors in the biosemiotic discourse and the nature-culture unity. The author discusses the notions of web and network applied to the biosemiotic theories. In the plan of theory, it is discussed with the reference to the notion of semiobiosphere understood as the complex of semiosphere (culture) and biosphere (nature) and, on the other hand, to the idea of considering the umwelt as a trans-sign network – as it was introduced by Susan Petrilli. The first is the extension of Juri Lotman’s semiosphere, the second is a conceptualization of the Uexküll’s term umwelt through translation studies. The other theoretical concept to be discussed in the talk is the notion of the umweb introduced by Kalevi Kull as a combination of umwelt term and the metaphor of the web and described as the series of correspondences. Both terms ‘network’ and ‘web’ are used within the discourse of humanities, i.e., for instance, in the anthropology of Bruno Latour. In the paper, the discussion on these notions’ circulation in the humanities and biosemiotics is followed by the introduction of the model of the Möbius strip which is used here to illustrate the nature-culture entanglement interestingly reflected by the above-mentioned notions. To conclude, two levels of reflection seem to be entangled: (1) scientific discourse itself and (2) the very spheres of nature and culture.