In recent years, semiotics of religion has become an established current in the broader field of semiotic studies (cf. research by Francesco Galofaro, Massimo Leone, Thomas-Andreas Põder, Jenny Ponzo, Fabio Rambelli, Robert Yelle, and many others). In the meantime, another relevant – albeit perhaps less diffused and structured – branch of studies has been developed under the label of “semio-ethics”. The latter tackles the relationship between sense, value and action, exploring fundamental issues concerning for instance the role of axiologies and ideologies in the determination of sense, and thus in shaping cultures and social practices. Important insights in this field have been first proposed by Charles Peirce, Charles Morris, and other exponents of the American and European semiotics, and have been further elaborated, particularly in Italy, by Susan Petrilli, Augusto Ponzio, Ferruccio Rossi-Landi, Ugo Volli, and other semioticians who have brought a relevant contribution to the development of a multifaceted research line that crosses the borders between (post-)structuralism and pragmaticism. This talk intends to explore the existing and the perspective relationships between semio-ethics and the semiotics of religion. On one hand, it focuses on the main theoretical and methodological suggestions deriving from semio-ethics that can serve as useful resources for further developments of the field of the semiotics of religion. On the other hand, it shows how the confrontation with religious and spiritual cultures has proved fruitful for the formulation of some aspects of the semio-ethical perspective.