Can semiotics account for “cultural perspectives”? Since the foundations established by Greimas in the 1970s, semiotics has gradually developed a toolkit that allows dealing with subjectivity. From this point there has been an analytical evolution of its conceptual - and analytical - framework, resulting in an approach of “cultures” centred on enunciation and experience (Fontanille 1999, 2015).In this context, the question of “perspectives” was nurtured by the encounter with the anthropology of Latour (1991, 2012), Descola (2005) and Viveiros de Castro (2009), whose works based on cognition, perception and experience (ontological turn), relocated “indigenous” points of view and categories to the centre of their field. In dialogue with these reflections, the current “culture-oriented” semiotics began criticizing its own models, in particular Greimas’ narrativity, Lotman’s semiosphere and even Levi-Strauss’ structural anthropology, which were judged to be insufficient to account for the multiple and different perspectives that inhabit the world, especially the “modern” world.In the context of this panel, the aim of our presentation is to re-examine these old models, considered as foundations of a semio-anthropology (Châtenet & Di Caterino 2021) in order to discuss how they are still relevant to analyse and describe cultures, considered as singular “semiotic worlds”, along with their own points of view or (multi)perspectives expressed through their discourses.