The relationship between being and being (Kush, 1998) challenges the theoretical approaches of semiotics, insofar as it is assumed as a body that explains the sign and signification, in the light of the semiosis provided by Latin American indigenous communities. In this space, the aim is to contribute to an ontological, gnoseological and epistemological reflection on the semiotics of culture (Lotman, 1999) and its strong links with the configuration of indigenous and popular knowledge in Latin America.Under this reflection, we seek to defend the conception of the sign-semiosis, from the vital metaphor of the seed and the relation of life with the organic and visceral manifestations that configure the place of Latin American cultures. Under a parallel with Western semiotics, the aim is to question the unrestricted and systematic character of the semiotic universe and its postulates, in order to assimilate the mechanisms of semiotic translation between the Western world and indigenous cosmogonies as explicit ways of conceiving knowledge and knowledge today. The degree of systematicity of the semiotic universe is questioned, insofar as semiosis proceeds from a sensitive and perceptible exercise, with which indigenous communities have elaborated their cosmogony of being. To this end, the theory of fagocitación (Kush, 1998) is proposed as a form of Latin American semiosis around the indigenous cosmogonies that have populated the Colombian and Latin American territory, long before Western colonisation.