Culture constitutes a very important sign in the bosom of social life, as a complex entirety that integrates language, economy, knowledge (technical, artistic, literary, etc.), and habits that rule the relations between individuals and groups. It concerns the objective civilization, the effort of adaptation of a human group making use of the entire human nature (intelligence, will, sensitivity, bodily activities), in order to protect the group against similar groups who would try to absorb it and to transmit to its lineage the global experience received from its initiators. We will have the opportunity to verify this in Cameroon through a scientific scrutinazation of the garment, as a sign of communication of culture.If we consider as postulate the fact that life is, in the sense of Shakespeare, a theater in which each human being behaves like an actor who comes on stage to play a precise part, one can observe that the garment appears as an important sign of social theatralization of the human being in society.The purpose of this paper is to highlight the value and efficiency of the garment considered in its different acceptations (traditional and associative uniforms, para-vestimentary, etc.), as an important mediation, insofar as it helps to accede to some deep meanings of the human being.Based on an eclectic approach, this paper emphasizes the federative nature of semiotics which thus can integrate sociology, anthropology, and psychoanalysis.