The present research starts from the visual products connected to the cult of Saint Cosmas and Damian, which represents the two brothers who flaunt the instrument of the sanitary profession.As is well known, the cult of the two brothers had great success under the reign of Justinian. The emperor suffered leg pain, perhaps edema or gums. According to Procopio of Cesarea, the disturbance at the legs was cured by the intercession of Saints Cosmas and Damian (Wirth G, Haury J, eds. Anecdota (Historia Arcana). In: Procopii Caesariensis Opera Omnia, Vol. III. Lipsiae: 283-284. BG Teubner, 1963: 56-68, 107-108). The cult is galvanized for political reasons bat achieves success in the popular environment because is focused on the curative attitude of the saints. And so, we observe that the representation of the two saints incorporates the presence of scalpel, phlebotomy, spatulas, and the relative cassettes for medical equipment. Instead, the hagiographic stories receive the locus that represents the two saints, who perform a normal medical examination, formulate a diagnosis, and then operate the wonderful. Paraphrasing Micheal McCormick, not even an inventive hagiographer or iconographer manage to invent some practices that are too far from everyday life, but both have to reflect the normal praxis and the common uses of health workers of their time (McCormick 2009, 574-575).In this way, we analyze the semiotic of the Christianism of the things, that are interested in receiving and metabolizing the objects of every day and using them for edifying purposes.