AcrossRCA is an interdisciplinary module offered to all postgraduate students at the Royal College of Art (London), inviting learners across all specialisms in the College to collaborate with peers from different professions and academic interests in responses to urgent contemporary issues. As a tutor leading six interdisciplinary and multicultural teams in responding to the theme of “Justice, Equality, and Misinformation”, I aim to present the semiotic pedagogical model emerging from my experience with the cohort, exploring a transposition of Jakob von Uexküll​’s theory of the umwelt to the cultural spheres and its significant dimensions. The work draws from my previously published research on the construction of critical and creative pedagogies through the intersection of traditional education theories with semiotic and philosophical postulates, as well as my works on identity and culture, which aimed to deconstruct superficial differences that justify arguments of “cultural difference”. Approaching professional and creative practice, as well as cultural backgrounds through the lenses of umwelten, the article makes a case for a pedagogical theory grounded in translation and the importance of building skills enabling subjects to mediate the encounter of umwelten as an engine for collaborative interdisciplinarity at the core of mitigating contemporary challenges. The successes from my 2023-24 AcrossRCA cohorts offer a case study for effective dialogue between the Arts and STEM disciplines, utilising postulates from Biosemiotics, Semiotics of Culture, and Generative Semiotics to respond to urgent crises of fragmentation of academic specialisms both at university and in industries.